@Kansas Terri, I'm stealing your term Midwest Casual!
Dr Case, question: I have a mess of grape ivy, nightshade and other stuff along one side of my house. Decided to eliminate it all to make room for perennials; digging it up would be ridiculously labor intensive. So Saturday morning I bought a gallon on RoundUp and sprayed it liberally. Sunday morning it was still looking quite perky, so I sprayed it again. Now it's Wednesday and while looking less-perky, many of the lower stems are still pliable and alive. Spray again, or wait some more, or start digging?
I just took this photo.